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KMID : 0903520060490040322
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Journal of the Korean Society of Agricultural Chemistry and Biotechnology
2006 Volume.49 No. 4 p.322 ~ p.327
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The Physical and Chemical Properties and Cytotoxic Effects of Acer tegmentosum Maxim. Extracts
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Shin In-Cheol
Sa Jae-Hoon
Shim Tae-Heum
Lee Jin-Ha
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Abstract
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Food constituents analysis of Acer tegmentosum. Maxim. (Acer TM) stem was carried out according to AOAC method, and the antiradical activity on DPPH and cytotoxicity on human cell lines (AGS, HepG2, A549, MCF-7 and Chang) for the 80% ethylalcohol (EtOH) extracts of Acer TM stem were studied. The antiradical activity on DPPH radical of the ethylacetate (EtOAc) fraction of the bark showed a higher activity than that of α-tocopherol, ascorbic acid and BHT. The inhibition activity of the 80% EtOH extracts from Acer TM stem on human cancer cell lines by SRB assay indicated a dose-dependent growth inhibition on most human carcinoma cells. The growth inhibition rate of each human cancer cell line showed 91.3% to AGS, 75.0% to A549, 74.1% to HepG2, and 70.2% to MCF-7 cells, respectively, when the 80% EtOH extract (1 mg/ml) of Acer TM stem was added.
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KEYWORD
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Acer tegmentosum Maxim, antiradical, DPPH, cytotoxicity, human cancer cell lines
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